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CANCER OF UNKNOWN PRIMARY FOUNDATION

OnHealthy

Presentations & summaries of papers delivered at CUP Foundation international conferences in London

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Webinar – 21 June 2022. Is the Unkown, now known’. A conversation with Dr Tony Greco and Dr Harpreet Wasan.

Link

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CUP 2019: Cancer of Unknown Primary in the Era of Precision Medicine

Opening

Conference programme and speakers

Wasan for Greco 

Current optimal tissue diagnostics for CUP

Schofield & Oien part one and part two[file too large and therefore broken into two]

Esteller [adapted slightly to fit]

Tothill part one and part two [file too large and therefore broken into two]

Current clinical and translational trials

Wasan 

Schofield

Kraemer part one[file too large and therefore broken into two] part two

Shiu (with CUPISCO slides removed)

Wasan for Greco

Optimal management and focus on the future

Wasan for Greco

Cook

Tothill [file too large to load]

Esteller

Debates

Reddy N/A

Cook

Kraemer

Wasan/Greco 

Winning Poster

Analysis of prognostic biomarkers in patients with cancer of unknown primary

CUP 2015 – Improving Patient Management & Outcomes

Conference programme and speakers

Poster Abstracts . The winning poster was Wagland et al, Soton Uni. Second equal: Schroeder et al, German Cancer Research Centre; Gilmore et al, Royal Free Hospital London.

Opening

Symons & Greco Introductory remarks

Part 1: Introduction

Pavlidis Overview of clinical presentation and treatment

Oien Histopathology

Vajdic Epidemiology

Part 2: Translational/ clinical research

Pavlidis Biology

GriffithsG Phenotypic screening

Greco USA research

Schofield  Australia research

Wasan UK research

Part 3: MDT perspectives

GriffithsR CUP MDT (Clatterbridge)

Ngan CUP MDT (GSTT)

Low CUP MDT (CNS perspective)

Part 4: Future perspectives

Caulfield 100K Genomes Project

Greco Controversy

CUP 2014 – The Management, Treatment and Future Perspectives of CUP

confCUP_2014_Logo_RGB

Background

The Seminar Programme and Speakers

Opening

Seminar objectives, backgound to CUP.  (9 mins) Dr John Symons and Prof Nicholas Pavlidis

Module 1 – The Epidemiology, Biology and Pathology of CUP

Epidemiology. (22 mins) Prof Kari Hemminki

Biology. (15 mins) Prof Nicholas Pavlidis/Dr George Pentheroudakis

Pathology. (27 mins) Dr. Karin Oien

Module 1 Discussion session (41 mins). Chair: Dr Harpreet Wasan

Module 2 – Diagnostic challenges, subsets and prognosis

The role of imaging. (35 mins) Dr Ben Taylor

The role of molecular profiling and new diagnostic technologies. (33 mins) Dr Robert Wassman

Natural history, clinicopathological subsets,and prognostic factors . (17 mins) Professor Nicholas Pavlidis

Module 2 Discussion session (21 mins). Chair: Dr Harpreet Wasan

Module 3 – Treating CUP

Treating favourable prognosis subsets. (18 Mins) Professor Nicholas Pavlidis

Treating CUP subsets by empirical or by molecular-assay directed treatment.  (10 mins) Prof Pavlidis/ Dr George Pentheroudakis

Ongoing clinical trials: CUP-One (UK). (18 mins) Dr Harpreet  Wasan &  SUPER (Australia) (15 mins). A/Professor Penelope Schofield

Module 3 Discussion  session (29 mins)

Module 4 – Guidelines, psychosocial aspects and palliative care

Existing CUP Guidelines (NICE, NCCN, ESMO); Criticism and perspectives.  (43 mins) Dr Richard Osborne/ Dr George Pentheroudakis

Psychosocial aspects facing CUP patients – UK perspective. (22 mins) Dr Carol Davis

Psychosocial aspects facing CUP patients – Australian perspective .  (12 mins) A/Professor Penelope Schofield

Module 4 Discussion session (40 mins)

Module 5 – Future perspectives

Defining actionable molecular phenotypes for therapy using Next Generation Sequencing. (29 mins) Prof. Andrew Biankin

Personalising cancer medicine – from CUP to site specific cancers and back again. (20 mins) Dr Harpreet Wasan

Module 5 Discussion session (6 mins)

CUP 2012

https://cupfoundjo.org/conference/conference_output.html [temp link to old website]

CONFERENCE_summary

Slides of presentations by:

Brooks; Greco; Osborne; Pavlidis; Schofield (molecular biology); Schofield(patient experience); Vajdic; WaglandWasan

CUP_Conf2012_Flyer3_A5

CUP 2009

The findings from the 2009 Conference were published in Annals of Oncology. 2012 Feb;23(2):298-304.  Greco FA, Oien K, Erlander M, Osborne R, Varadhachary G, Bridgewater J, Cohen D, Wasan H. Cancer of Unknown Primary: Progress in the Search for Improved and Rapid Diagnosis Leading Toward Superior Patient Outcomes.

Specific presentations transcripts from CUP 2009 are shown below:

Diagnostic_Strategies_(Varadhachary)

Palliative_care_(Davis)

Research-Diagnosis_and_Treatment (Bridgewater)

The_pathology_work-up_(Oien)

Expert_Panel-Molecular_Profiling

Failing_the_CUP_patient_(Osborne)

diagnosis_of_metastatic_cancer_by_molecular_classification

CUP-One_Trial_(Wasan)

MicroRNA Profiling (Cohen)

Keynote_(Greco)

conf12greco   confCUP_2014_Logo_RGB  conf09
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