The 2020/2021 National Genomic Test Directory for cancer specifies the genomic tests commissioned by the NHS in England for cancer, the technology by which they are available, and the patients who will be eligible to access to a test. National Genomic test directory for cancer can be found here. It is then necessary to open an Excel spreadsheet and CUP
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For information about the rollout of Rapid Diagnostic Centres see here
We rely on the excellent stats department of CRUK and the latest available year’s (2017) incidence and mortality data for CUP are shown below: CUP incidence UK total: 8341. About 24 people a day in the UK receive a new CUP diagnosis. It is the 15th most common UK cancer (11th most common in females and 14th most common in
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The Government has launched the new National Genomic Healthcare Strategy – “Genome UK: the future of healthcare” – setting out how the genomics community will come together to harness the latest advances in genetic and genomic science, research, and technology to create the most advanced genomic healthcare system in the world. The Strategy is aimed at driving improvements in healthcare
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The NHS has entered the ‘third phase’ of the pandemic response, effective from 1 August 2020, with the ambition of restoring full operation of all cancer services. The NHS Chief Executive requires Trusts to achieve: • In September at least 80% of their last year’s activity for both overnight electives and for outpatient/day case procedures, rising to 90% in October
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SUPER is an Australian CUP trial that has been running for some time and as part of it SUPER-NEXT, led by Richard Tothill, will evaluate WGS when used to help resolve a tumour type diagnosis and improve therapeutic decision making in CUP.
The recent ASCO Virtual included a session on CUP under the heading ‘Redefining Cancer of Unknown Primary: Is Genomics the Answer?’ The Discussants were Tony Greco (USA) and Karim Fizazi (Fr) and papers were from Australia, USA, Japan, and China. Further details and the abstracts (which can been seen without logging into an ASCO account) are shown here.
On the latest update to the Greco and Hainsworth Wolters Kluwer ACUP publication it is interesting that they have changed the treatment flow chart now differentiating between ‘treatment sensitive cancer type’ and the ‘treatment-resistant cancer type’.
From March 2012 to February 2018, 243 CUP patients from 4 EU countries took part in a Phase III trial (GEFCAPI 04) led by Dr Fizazi in France. The aim was to see if tailored treatment following molecular profiling would improve outcomes; but the results, reported in the Autumn of 2019, showed no significant improvement in outcomes overall. There was
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The official website for World Cancer Day states that the aim is to ‘recognise that our commitment to act will lead to powerful progress in reducing the global impact of cancer….We need your commitment to create a cancer-free world. CUP Foundation – Jo’s friends is totally supportive of taking a global view – embracing research expertise around the world to
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