Whole Genome Sequencing (WGS) becomes Standard of Care for CUP patients. Cancer of Unknown Primary (CUP) WGS in all ages and in upfront testing is included in the National Genomic Test Directory in the 31st October 2022 publication as a standalone referral indication (M226.4). The National Genomic Test Directory specifies which genomic tests are commissioned by NHS England, the patients that areRead more
For some time we have been pressing for clarification on Whole Genome Sequencing (WGS) in relation to Standard of Care (SOC) for CUP patients. The all-important Test Directory is to be updated shortly and Professor Dame Sue Hill, Chief Scientific Officer for England and SRO for NHS Genomics has advised us that: ‘CUP WGS in all ages and in upfrontRead more
Research by Natalie Cook’s CUP group at the Christie in Manchester has shown that a significant number of provisional CUP patients can be put onto a site specific pathway for Intrahepatic cholangiocarcinoma. “By reclassifying some of those CUP patients with cancer in the liver as bile duct cancer patients, this would lead to increased treatment options and a better prognosis.Read more
Encouraged from a number of sides, NICE have decided that an update to the Guideline is not presently warranted. A slight glimmer of light is shown in their statement that ‘we do feel that this area is moving but there is not yet sufficient evidence for us to suggest an update. We are tracking a number of ongoing trials whichRead more
31 October 2022 has been confirmed as the last date at which patients globally may be entered into screening for the trial. All patients screened on or prior to 31 Oct 2022 will continue in the study as usual i.e. eligibility review, induction chemotherapy, MTB (if applicable) and Treatment phase.
A reminder that CUP-COMP is recruiting up to 120 patients by December 2022. The trial, led by the Christie, is to assess and compare genomic sequencing in tissue and blood for the diagnosis and treatment stratification of CUP patients. More info
We have just become aware of the death of Prof. Gauri Varadhachary who died in August 2021 aged 52. Those who attended our 2009 international conference in London where she was a distinguished speaker will remember her. An oncologist at MD Anderson, she made a very significant contribution to CUP research and treatment. Obituary: Dr. Gauri Varadhachary (india-herald.com)
On our previous post we wrote on 5 May: Clinicians are now able to request whole genome sequencing (WGS) at the North West NHS Genomic Laboratory Hub for eligible patients with CUP in their care. This is a very significant step forward and excellent news. We are trying to find out from the NHS National Genomic Medicine Service whether WGS inRead more
Clinicians are now able to request whole genome sequencing (WGS) at the North West NHS Genomic Laboratory Hub for eligible patients with CUP in their care. This is a very significant step forward and excellent news. We are trying to find out from the NHS National Genomic Medicine Service whether WGS in tissue extends to other regions.