Use the search to find what you are looking for



12 Apr 2017

NICE have decided not to review the CUP Guideline having been advised of advances in immunohistochemistry markers and molecular profiling since the guideline was developed. The decision is shown here and, more interestingly, the evidence on which the decision was made is shown here. The recommendations from the review question are: Immunohistochemistry Use a panel of antibodies comprising cytokeratin 7 (CK7),Read more

15 Mar 2017

The abstract from a recent paper in Internal Medicine Journal makes for very interesting, if scary, reading: ‘Perceptions of Cancer of Unknown Primary Site – A National Survey of Australian Medical Oncologists: Australian Medical Oncologist CUP survey’ (Christos S Karapetis et al, Jan 2017).  The authors include Penny Schofield of our Advisory Board. The researchers invited all members of the Medical OncologyRead more

19 Feb 2017

In 2015 Jo’s friends director was invited to join an international group to begin to identify the big problems that a massive research grant (£20M) might encourage cancer scientists to try and solve. This is an exciting and novel approach to speed-up the search for cancer solutions outside the cumbersome, bureaucratic and slow research processes that characterize cancer research inRead more

30 Jan 2017

With Southampton University and the Peter MacCallum Cancer Centre in Australia we have been carrying out various studies over recent years to try and understand the experiences of CUP patients and their families. The latest study, in progress, is to compare CUP patients with patients who have site-specific metastatic cancers (colorectal, breast, head and neck, kidney/adrenal, prostate, pancreas, and upperRead more

12 Jan 2017

We continually make the cry that we need more research into CUP: it’s biology, CUP diagnosis, the efficacy of treatment regimens, the value of molecular profiling, patient experience etc. Very little clinical or translational research has been funded in the UK with the exception of CUP One which is a National Cancer Research Institute (NCRI) trial. Findings are due this year.Read more

03 Jan 2017

Cancer Research UK do a great job in presenting cancer data drawn from the Office of National Statistics. The data on CUP is now presented in a very visible way. You can view it here. You need to remember that the data are for the latest year available and this is 2014. The main points are: UK CUP incidence is downRead more

18 Dec 2016

Dr William King, Consultant Radiologist, St Mary’s Hospital, Isle of Wight writes: as soon as a radiologist gets a whiff that someone has cancer we shout it from the treetops to the people that matter, not just the person who has sent them for the scan. Following a discussion with an oncologist during the 2016 CUP Peer Review process, thatRead more

16 Dec 2016

One of the commonest discussion threads on the Forum has been about gene expression profiling and I’m carrying forward my response to the latest exchange between patients and carers here in case it is helpful to others. To focus targeted treatment it is not the primary anatomical site itself that is important but the molecular profile of the disease (cancers, even in anRead more

16 Dec 2016

We welcome contributions to this blog sent to with your name for publication.  Opinions, insights, experiences,  welcome. We reserve the right to edit or not publish. Jo’s friends cannot comment on specific medical queries. Views expressed here should not be used as a substitute for medical or other professional advice. The Blog replaces the Forum which we have had toRead more

16 Dec 2016

A conference was held on 6 December 2016 in London primarily for CUP keyworkers run by SBK and supported by the CUP Foundation. Topics included: The role of leadership in optimizing the CUP MDT; a summary of the 2016 external peer review by QST; the role of histopathology and radiology and palliative care in the CUP patient journey; good practiceRead more