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01 Jun 2017

The charity is 10 years old. To mark this, the Director has written a paper looking at the last ten years of CUP: the past, the current ‘state of play’, and a peek into the future. His thesis is that ‘the future is already here but it is not evenly distributed’.

26 May 2017

Molecular profiling to determine the tissue of origin of a patient’s CUP is not routinely undertaken in the UK – yet it is often a helpful aid to achieving an accurate diagnosis to allow focused treatment with confidence. The NHS need to be convinced of the cost/benefits of molecular profiling for CUP patients. A Canadian study has investigated the cost-effectiveness ofRead more

19 May 2017

We are an apolitical charity but on the realistic grounds that the Conservatives are most likely to regain power at the General Election it is interesting to note their manifesto commitment to: ‘continuing to support research into the diagnosis and treatment of rare cancers and other diseases, including Genomics England’s work in decoding 100,000 genomes’. What does it mean beyondRead more

12 Apr 2017

NICE have decided not to review the CUP Guideline having been advised of advances in immunohistochemistry markers and molecular profiling since the guideline was developed. The decision is shown here and, more interestingly, the evidence on which the decision was made is shown here. The recommendations from the review question are: Immunohistochemistry Use a panel of antibodies comprising cytokeratin 7 (CK7),Read more

15 Mar 2017

The abstract from a recent paper in Internal Medicine Journal makes for very interesting, if scary, reading: ‘Perceptions of Cancer of Unknown Primary Site – A National Survey of Australian Medical Oncologists: Australian Medical Oncologist CUP survey’ (Christos S Karapetis et al, Jan 2017).  The authors include Penny Schofield of our Advisory Board. The researchers invited all members of the Medical OncologyRead more

19 Feb 2017

In 2015 Jo’s friends director was invited to join an international group to begin to identify the big problems that a massive research grant (£20M) might encourage cancer scientists to try and solve. This is an exciting and novel approach to speed-up the search for cancer solutions outside the cumbersome, bureaucratic and slow research processes that characterize cancer research inRead more

30 Jan 2017

With Southampton University and the Peter MacCallum Cancer Centre in Australia we have been carrying out various studies over recent years to try and understand the experiences of CUP patients and their families. The latest study, in progress, is to compare CUP patients with patients who have site-specific metastatic cancers (colorectal, breast, head and neck, kidney/adrenal, prostate, pancreas, and upperRead more

12 Jan 2017

We continually make the cry that we need more research into CUP: it’s biology, CUP diagnosis, the efficacy of treatment regimens, the value of molecular profiling, patient experience etc. Very little clinical or translational research has been funded in the UK with the exception of CUP One which is a National Cancer Research Institute (NCRI) trial. Findings are due this year.Read more

03 Jan 2017

Cancer Research UK do a great job in presenting cancer data drawn from the Office of National Statistics. The data on CUP is now presented in a very visible way. You can view it here. You need to remember that the data are for the latest year available and this is 2014. The main points are: UK CUP incidence is downRead more

18 Dec 2016

Dr William King, Consultant Radiologist, St Mary’s Hospital, Isle of Wight writes: as soon as a radiologist gets a whiff that someone has cancer we shout it from the treetops to the people that matter, not just the person who has sent them for the scan. Following a discussion with an oncologist during the 2016 CUP Peer Review process, thatRead more