On 12 June 2018 in Bristol there is a day’s event designed for those working in CUP MDTs to come together and share experiences. Topics include: diagnostic challenges including developments in pathology, palliative care, clinical trials, developing urgent referral pathways and patient surveys. The speakers are all practitioners and this is a great opportunity to benchmark your service delivery withRead more
The 100,000 Genomes Project reached the halfway point, with 50,065 whole genomes sequenced, this week. This is a pretty impressive achievement by Genomics England. The figure will include some CUP patients. There is unlikely to be any immediate benefit for CUP patients but it promises to be an amazing resource for scientists trying to understand some cancers and other diseases.
Following the 2016 external peer review of CUP services in England in 2016, we have been chasing the report. We’ve been pressing the Quality Surveillance Team (Specialised Commissioning, NHS England) for a year and have had various assurances, at different times, of its forthcoming availability. The latest response from the Deputy Head of Quality Surveillance Team of 20 Feb 2018Read more
We have been pressing the Quality Surveillance Team to release the report on the external peer review that took place in 2016. The latest from the Deputy Head of the Quality Surveillance Team is that ‘The report will be available to NHS England colleagues and stakeholders at the end of January beginning of February 2018. It is currently being prepared.’
ESMO have produced a useful patient-oriented guide on immunotherapy side effects ESMO-Patient-Guide-on-Immunotherapy-Side-Effects
A recent review and meta-analysis of 18F-FDG PET/CT for detection of the primary tumor in adults with extracervical metastases from cancer of unknown primary is available in the publications area of our research section.
An interesting short article in NEJM here . Particularly relevant as we work on the development of a Patient Decision Aid for CUP. The concluding paragraph gives a flavor: “Regret is typically viewed as a negative emotion. It is notable that existing patient regret scales have largely failed to assess for a positive impact of regret. However, awareness of regret canRead more
Pharmaceutical company Roche is to sponsor a multi-country, Phase II, genomic profiling study to evaluate the efficacy of molecularly guided therapy versus platinum chemotherapy in CUP patients. Profiling will be based on the FoundationOne® assay. It is intended that the trial should open in approximately 100 sites in 25 countries and will enroll 790 patients. Last week it was agreed,Read more
A very exciting PhD research project has started at the Cancer Research UK Manchester Institute. CRUK Clinical research fellow, Dr Alicia Conway, is to test the hypothesis that liquid biomarkers, including but not limited to ctDNA, circulating tumours cells (CTCs) and tumour educated blood platelets, can be used to detect tissue of origin and molecular subtypes in patients with carcinomaRead more
Perhaps a bit ‘left field’ but interesting for its similarities with humans, an article on CUP in dogs by Rossi et al can be found here on PubMed. This is the abstract: The aim of this retrospective study was to describe clinical features, treatment and outcome of 21 dogs with metastatic cancer of unknown primary (MCUP), a biopsy-proven malignancy beingRead more