The outline timings for the day are 0900 – 1730 hours with check-in from 0830. Refreshments, lunch and programme materials are included in the delegate fee. Drinks and poster prizes at 1730.
The detailed programme is to follow but in outline:
Session 1: Current optimal diagnostics for CUP tissue of origin. Invited speakers followed by panel and audience discussion
- State of the art immunohistochemistry for the diagnosis of tissue of origin
- Evolving morphomolecular pathology in the diagnosis of the tissue of origin
- Progress, accuracy and limitations of molecular cancer classifier assays: Review of various assays
- The usefulness and potential of the epigenetic/methylation assay (EPICUP) for tissue of origin diagnosis
- Comprehensive genomic profiling of CUP: Therapeutic implications
Session 2: Clinical and translational trials. Invited speakers followed by panel and audience discussion
- State of play of clinical trials around the world
Session 3: Optimal clinical management and focus on the future. Invited speakers followed by panel and audience discussion
- Integration of a molecular cancer classifier and comprehensive molecular profiling in selected patients
- Review of future technologies including liquid biopsies and circulating tumour cells
- Potential of nanostring technology and search for a CUP genetic/epigenetic signature
- The Cancer genome atlas (TCGA) and search for a CUP genetic/epigenetic signature
- Debate: – CUP is a single type of cancer with unique biology and response to therapies? – CUP is many specific cancer types with occult primaries but predictable responses to therapies? – Comprehensive molecular profiling should be the preferred test rather than a molecular cancer classifier assay?