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CANCER OF UNKNOWN PRIMARY FOUNDATION

OnHealthy

Programme

The outline timings for the day are 0900 – 1730 hours with check-in from 0830.  Refreshments, lunch and programme materials are included in the delegate fee.  Drinks and poster prizes at 1730.

The detailed programme is to follow but in outline:

Session 1:  Current optimal diagnostics for CUP tissue of origin. Invited speakers followed by panel and audience discussion

Planned Topics:

  • State of the art immunohistochemistry for the diagnosis of tissue of origin
  • Evolving morphomolecular pathology in the diagnosis of the tissue of origin
  • Progress, accuracy and limitations of molecular cancer classifier assays: Review of various assays
  • The usefulness and potential of the epigenetic/methylation assay (EPICUP) for tissue of origin diagnosis
  • Comprehensive genomic profiling of CUP: Therapeutic implications

Session 2:  Clinical and translational trials. Invited speakers followed by panel and audience discussion

  • State of play of clinical trials around the world

Session 3:  Optimal clinical management and focus on the future. Invited speakers followed by panel and audience discussion

Planned Topics:

  • Integration of a molecular cancer classifier and comprehensive molecular profiling in selected patients
  • Review of future technologies including liquid biopsies and circulating tumour cells
  • Potential of nanostring technology and search for a CUP genetic/epigenetic signature
  • The Cancer genome atlas (TCGA) and search for a CUP genetic/epigenetic signature
  • Debate: – CUP is a single type of cancer with unique biology and response to therapies? – CUP is many specific cancer types with occult primaries but predictable responses to therapies? – Comprehensive molecular profiling should be the preferred test rather than a molecular cancer classifier assay?