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Whole Genome Sequencing (WGS) for CUP patients in England

October 11, 2022

For some time we have been pressing for clarification on Whole Genome Sequencing (WGS) in relation to Standard of Care (SOC) for CUP patients. The all-important Test Directory is to be updated shortly and Professor Dame Sue Hill, Chief Scientific Officer for England and SRO for NHS Genomics has advised us that:

‘CUP WGS in all ages and in upfront testing will be included in the Test Directory  in the 31st October 2022 publication as a standalone referral indication (M226.4). Samples in this setting are already being submitted for WGS either via the paediatric cancer route or as M232.1 – solid tumours which have exhausted standard of care testing. As CUP primary tumour site is not identified then SOC has been exhausted and therefore are eligible. We know that samples are being submitted across the country’.

WGS explained

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