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Hainsworth & Greco ask some questions in their latest paper which they go on to answer: (1) Do patients with unknown primary site actually have a primary site? (2) Do CUPs mirror their counterparts that present with overt primary sites in most aspects of tumor biology, even though they diﬀer in the ability to metastasize widely (mechanism unknown) while the primary tumor remains small? (3) Do CUPs respond to the same treatments proven eﬀective in patients with the corresponding cancers of known primary site?
Cancer of Unknown Primary Site: New Treatment Paradigms in the Era of Precision Medicine. John D. Hainsworth and F. Anthony Greco. Downloaded from ascopubs.org on July 17, 2018. American Society of Clinical Oncology