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Pathology is critical to an accurate diagnosis of cancer – and for getting the best possible clues to aid treatment from the tissue of a patient where a site-specific diagnosis remains elusive. There are very few pathologists with expertise in CUP so it is good news – if not overdue news – that The Royal College of Pathologists have drafted a ‘dataset’ (essentially, a guide) to help pathologists through this difficult area. The draft dataset will shortly be going out for consultation.