NICE have decided not to review the CUP Guideline having been advised of advances in immunohistochemistry markers and molecular profiling since the guideline was developed. The decision is shown here and, more interestingly, the evidence on which the decision was made is shown here. The recommendations from the review question are: Immunohistochemistry 1.2.2.7 Use a panel of antibodies comprising cytokeratin 7 (CK7),Read more